Endocrine Abstracts

Objective: To construct rat congenic strains to confirm and narrow down a region on rat chromosome 2 previously implicated in blood pressure regulation. To determine expression profiles and identify differentially expressed genes between congenic strain and respective parental strain using microarray technology.Design and Methods: Total RNA was prepared from whole kidney homogenates from 2x parental SHRSPGla and 2x SP.WKYGla2a congenic rats. Expression ...

Objective. The aims of our study were to utilise a combination of high fidelity phenotyping, microarray gene expression profiling and conserved synteny mapping between rodent and human genomes to identify genetic determinants underlying human hypertension.Methods. We used the stroke-prone spontaneously hypertensive rat (SHRSP) and a congenic strain (SP.WKYGla2c*) produced by introgressing a quantitative trait locus responsible for blood pressure regulation on rat chromosom...

BackgroundIncreasing incidence of thyroid cancer together with improved prognosis raises a concern regarding development of second primary cancers. Moreover, little is known about the incidence of thyroid cancer as a second primary neoplasm after other cancers.MethodsA cohort of 39002 people (356034.5 person years) with primary thyroid cancer was identified in 13 population-based cancer registries in Europe, ...